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Related Experiment Video

Updated: Feb 3, 2026

A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants
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Initial experience with the precision neuroscience Layer 7 micro-electrocorticography interface for real-time

Kurt R Lehner1, Shiyu Luo2, Becca Greene2

  • 11Department of Neurosurgery, Johns Hopkins Hospital, Baltimore.

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Summary

High-density micro-electrocorticography (μECoG) enabled real-time speech and cursor control during surgery. This technology shows promise for future brain-computer interfaces (BCIs) in patients with motor and communication deficits.

Keywords:
brain-computer interfacebrain-machine interfacecursor controlelectrocorticographyintraoperative recordingsmicro-electrocorticographyneural decodingspeech synthesis

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Technology

Background:

  • Brain-computer interfaces (BCIs) offer potential solutions for individuals with severe motor and communication impairments.
  • High-density micro-electrocorticography (μECoG) arrays are being developed for advanced neural recording.
  • Intraoperative feasibility of novel μECoG devices for real-time BCI applications requires evaluation.

Purpose of the Study:

  • To assess the feasibility of the Layer 7 Cortical Interface, a high-density μECoG array, for intraoperative neural recordings.
  • To evaluate its utility in real-time brain-computer interface (BCI) applications, specifically speech decoding and cursor control.
  • To determine the safety and efficacy of the device during awake craniotomy for tumor resection.

Main Methods:

  • Four patients undergoing awake craniotomy for tumor resection were enrolled.
  • The Layer 7 μECoG device (1024 channels) was placed on the motor cortex.
  • Intraoperative tasks included joystick-controlled movement and auditory-cued speech repetition, with real-time decoder training.

Main Results:

  • The Layer 7 device was well-tolerated, with no device-related adverse events.
  • Stable, high-resolution cortical recordings were achieved throughout tumor resection.
  • Accurate real-time speech classification (77.5%) and cursor control (78%-84%) were demonstrated intraoperatively.

Conclusions:

  • The Layer 7 Cortical Interface facilitates high-resolution, nonpenetrating intraoperative cortical recordings.
  • It supports real-time speech classification and cursor control within a surgical timeframe.
  • High-density μECoG holds significant potential for intraoperative functional mapping and future chronic BCI systems.