A self-setting magnesium phosphate bone putty for effective hemostasis and osteogenesis in bleeding bone defect

Area of Science:

• Biomaterials Science
• Orthopedic Surgery
• Regenerative Medicine

Background:

• Intraoperative bleeding and bone defects complicate surgical outcomes.
• Traditional bone wax is bioinert, causing inflammation and hindering bone healing.
• Existing absorbable alternatives lack fluid resistance and adhesion for dynamic surgical sites.

Purpose of the Study:

• To develop a self-setting, fluid-resistant bone putty (MPP) for effective intraoperative hemostasis.
• To evaluate MPP's dual hemostatic and osteogenic capabilities.
• To compare MPP's performance against traditional bone wax in vivo.

Main Methods:

• Formulation of MPP using magnesium oxide, dipotassium hydrogen phosphate, and a starch-PEG matrix.
• In vitro assessment of underwater adhesion, liquid sealing, hemocompatibility, and cytocompatibility.
• In vivo evaluation in rat models for hemostasis and bone regeneration.

Main Results:

• MPP demonstrated rapid in situ solidification and fluid resistance in aqueous environments.
• The material showed gradual degradation, good hemocompatibility, and enhanced osteoblast activity.
• In vivo studies confirmed MPP's superior hemostasis and bone regeneration compared to bone wax.

Conclusions:

• MPP is a promising self-setting, fluid-resistant orthopedic hemostatic agent.
• The putty effectively controls bleeding and promotes bone regeneration.
• MPP offers a significant advancement over traditional bone wax for orthopedic applications.