Related Experiment Video
Updated: Feb 3, 2026
06:09
Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
Published on: May 30, 2025
796
30 Years of Developing Inhaled Insulin.
1Department of Medicine and Diabetes Research Instiitute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Diabetes Technology & Therapeutics
|February 1, 2026
Summary
Since 1921, insulin formulations have advanced to better mimic natural insulin secretion for diabetes management. This review focuses on the 30-year evolution of inhaled insulin products.
Area of Science:
- Endocrinology
- Pharmacology
- Diabetes Research
Background:
- The discovery of insulin in 1921 revolutionized diabetes treatment.
- Continuous innovation aims to improve insulin delivery, closely matching physiological secretion patterns.
- This is crucial for managing type 1 diabetes and insulin-requiring type 2 diabetes.
Purpose of the Study:
- To provide a concise review of inhaled insulin development over the last three decades.
- To highlight key milestones in the evolution of this alternative insulin delivery method.
Main Methods:
- Literature review of scientific publications and product development timelines.
- Analysis of key innovations in inhaled insulin formulation and delivery technology.
Main Results:
- Inhaled insulin offers an alternative to injectable forms, aiming for rapid absorption.
- Development has focused on improving efficacy, safety, and patient convenience.
- The past 30 years have seen significant, though sometimes challenging, progress.
Conclusions:
- Inhaled insulin represents a notable advancement in diabetes care, offering a non-injectable option.
- Ongoing research and development continue to refine inhaled insulin therapies.
- The journey of inhaled insulin underscores the drive for better diabetes management tools.
More Related Videos
05:07Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles
Published on: March 18, 2019
6.8K
05:52Insulin Injection and Hemolymph Extraction to Measure Insulin Sensitivity in Adult Drosophila melanogaster
Published on: June 30, 2011
20.4K
Related Concept Videos
01:23Inhaled Medications
801
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
801
01:24Pulmonary Ventilation: Inhalation
8.1K
Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
Boyle's law becomes particularly pertinent when examining respiratory...
8.1K
01:20Inhalational Anesthetics: Overview
1.1K
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
1.1K
01:05Insulin Secretory Vesicles
6.9K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
6.9K
01:28Insulin: The Receptor and Signaling Pathways
3.2K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
3.2K
01:27Insulin Formulations: Types and Delivery
735
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
Short-acting insulins are divided into...
735