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Updated: Feb 3, 2026

Electrochemically and Bioelectrochemically Induced Ammonium Recovery
Published on: January 22, 2015
H-Bond- and Strain-Release-Guided Photoreaction of Alkenes, p-Quinone Methides, and Ammonium Thiocyanate
Jobsy Jose1,2, Arun Yadav1,2, Saumya Singh1
1Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Abstract:
Spiro-cyclobutanes are sp3-rich molecules with applications in synthetic chemistry and drug discovery. The existing literature focuses mainly on their synthesis via the metal-catalyzed functionalization of substrates, such as spiro-cyclobutenes. In this letter, we disclose a H-bond-directed photochemical synthesis of densely substituted spiro-cyclobutanes. Moreover, a strain-release- and H-bond-directed three-component reaction of alkenes, p-quinone methide, and NH4SCN is also discussed. The reaction outcome is explained through control experiments and DFT calculations.
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