Related Experiment Video

Updated: Feb 4, 2026

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

16.5K

The role of ASIC2 in glioma progression: implications for prognosis and therapeutic targeting

Wenxiu Tian1, Yu Wang1, Zhenming Wang2

  • 1School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.

Peerj
|February 2, 2026
PubMed

Insights

Downregulation of acid-sensing ion channel 2 (ASIC2) in glioma correlates with poor survival and increased malignancy. Targeting ASIC2 may offer a new therapeutic strategy for glioma treatment.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cancer Genomics

Background:

  • Glioma is the most common primary brain tumor, known for its aggressive nature and poor prognosis.
  • Current treatments like surgery, radiotherapy, and chemotherapy have limited efficacy against glioma.
  • The Cancer Genome Atlas (TCGA) dataset analysis is crucial for understanding glioma's molecular landscape.

Purpose of the Study:

  • To investigate the role of acid-sensing ion channel 2 (ASIC2) in glioma.
  • To explore the correlation between ASIC2 expression and glioma patient survival.
  • To elucidate the molecular mechanisms by which ASIC2 influences glioma progression.

Main Methods:

  • Analysis of The Cancer Genome Atlas (TCGA) dataset for ASIC2 expression in glioma.
  • Correlation analysis between ASIC2 levels, patient survival, immune cell infiltration, and glioma stem cell markers.
  • Functional experiments involving ASIC2 knockdown and overexpression in glioma cells.

Main Results:

  • ASIC2 expression is significantly downregulated in glioma tissues and inversely correlates with patient survival.
  • Reduced ASIC2 expression is associated with increased immune cell infiltration and higher glioma stem cell marker levels.
  • ASIC2 modulates glioma cell proliferation, invasion, and metastasis via MMP2, calcineurin, and NFAT1 signaling pathways.

Conclusions:

  • ASIC2 plays a critical role in regulating the malignant behavior of glioma.
  • ASIC2 downregulation is a significant indicator of poor prognosis in glioma patients.
  • ASIC2 represents a potential molecular target for novel glioma therapeutic interventions.
Keywords:
ASIC2GliomaInvasionMetastasisProliferation

More Related Videos

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions07:39

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Published on: November 17, 2021

4.0K
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

17.5K

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.8K
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
The Role of Culture01:23

The Role of Culture

Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
419
Therapeutic Communication01:30

Therapeutic Communication

Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
8.1K