Related Experiment Video
Updated: Feb 4, 2026

Immunohistochemistry on Paraffin Sections of Mouse Epidermis Using Fluorescent Antibodies
Published on: January 8, 2008
Role of immunohistochemistry in differentiating between reactive and malignant lymphoid hyperplasia - A
Sakshi Chourasia1, Seema Badkur2, Ajit Kumar3
1Department of Pathology, Government Medical College, Satna, Madhya Pradesh, India.
Abstract:
Differentiating reactive lymphoid hyperplasia from malignant lymphoma poses a diagnostic challenge due to overlapping clinical and histopathological features. Therefore, it is of interest to evaluate the utility of immunohistochemistry (IHC) in distinguishing benign reactive changes from malignant lymphoid proliferations. Lymph node biopsies from patients presenting with persistent lymphadenopathy were assessed histologically and subjected to a panel of IHC markers including CD3, CD20, CD10, BCL2 and Ki-67. The analysis revealed that IHC not only confirmed lineage specificity but also helped to identify aberrant antigen expression and proliferative indices characteristic of malignancy. Thus, we show the pivotal role of IHC in improving diagnostic accuracy, reducing misclassification and guiding appropriate therapeutic decisions in patients with lymphoid hyperplasia.
More Related Videos
Related Concept Videos
Cross-Sectional Research
Cross-reactivity
Finding Volume Using Cross-Sectional Area
Profile Leveling and Cross Sections
Spinal Cord: Cross-sectional Anatomy
Gray Matter and its Components
Central to the gray matter is...
Crossing Over
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...

