Related Experiment Video

Updated: Feb 4, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Impact of cardiac resynchronization therapy in patients with left ventricular assist devices: A systematic review and

Miloud Cherbi1, Paul Gautier1, Raphael Martins2

  • 1Cardiology Department, Toulouse University Hospital, Toulouse, France.

JHLT Open
|February 2, 2026
PubMed

Insights

Cardiac resynchronization therapy (CRT) offers no survival or hemodynamic benefits for patients with left ventricular assist devices (LVADs). Further research is needed to determine CRT

Area of Science:

  • Cardiology
  • Medical Devices
  • Clinical Outcomes Research

Background:

  • Many patients with left ventricular assist devices (LVADs) also receive cardiac resynchronization therapy (CRT).
  • The clinical and hemodynamic impact of CRT in LVAD patients is not well understood.

Purpose of the Study:

  • To systematically review and perform a meta-analysis evaluating the impact of CRT on survival and clinical outcomes in patients with LVADs.
  • To assess the effect of CRT on key hemodynamic parameters in LVAD recipients.

Main Methods:

  • Systematic review and meta-analysis of studies from PubMed, EMBASE, and Cochrane databases up to April 30, 2025.
  • Primary outcome: all-cause mortality. Secondary outcomes: ventricular arrhythmias, device shocks, and various hemodynamic measures.
  • Included 13 studies with a total of 3,665 patients.

Main Results:

  • CRT did not significantly improve survival in LVAD patients across various comparisons (CRT-D vs. ICD, CRT on vs. off, CRT vs. no device).
  • No significant differences were observed in ventricular arrhythmias or device shock rates with CRT.
  • Biventricular pacing showed no hemodynamic advantages compared to right ventricular pacing or intrinsic rhythm.

Conclusions:

  • This meta-analysis indicates that CRT is not associated with improved survival or hemodynamic function in LVAD recipients.
  • Further randomized controlled trials are recommended to clarify CRT's role and identify optimal patient selection criteria for LVAD patients.
Abstract

Keywords:
Cardiac resynchronization therapyHeartmateHeartwareLeft ventricular assist deviceVentricular arrhythmiaVentricular fibrillationVentricular tachycardia

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