Immunoglobulins in healthy subjects and blood donors

Levels of immunoglobulins in serum were determined in 41 healthy subjects and 128 professional blood donors. In healthy subjects mean levels +/- S.D. were: IgG 1260 +/- 492.9 mg/dl, IgM 62.4 +/- 18.2 mg/dl, and IgA 183.4 +/- 70.1 mg/dl. Of 128 blood donors 112 were hepatitis Bs antigen (HBsAg) negative and 16 were positive. A significant (P is less than 0.001) elevation of all three immunoglobulins was observed in HBsAg positive group suggesting increased antibody formation due to persistance of antigen.