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Precision Medicine in Disorders of Gut-Brain Interaction
Brian E Lacy1, Hasan Saleh2, David J Cangemi1
1Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida.
Gastroenterology & Hepatology
|February 2, 2026
Summary
Precision medicine, which tailors treatments using patient-specific data, offers potential for disorders of gut-brain interaction (DGBIs). This approach can improve diagnosis and therapy for prevalent DGBIs like IBS.
Area of Science:
- Gastroenterology
- Genetics
- Internal Medicine
Background:
- Precision medicine leverages individual genetic, environmental, and lifestyle data for disease prevention, diagnosis, and treatment.
- While established in oncology, precision medicine's application in disorders of gut-brain interaction (DGBIs) remains limited.
- DGBIs affect 40% of the global population, including conditions like functional dyspepsia and irritable bowel syndrome, significantly impacting quality of life and healthcare systems.
Purpose of the Study:
- To define precision medicine and differentiate it from personalized medicine.
- To explore the potential application of precision medicine in managing DGBIs.
- To outline a strategy for implementing precision medicine in DGBIs.
Main Methods:
- Literature review defining precision medicine and its contrast with personalized medicine.
- Discussion of current and potential uses of precision medicine in DGBIs.
- Analysis of limitations and proposal of a strategic framework for precision medicine in DGBIs.
Main Results:
- Precision medicine utilizes comprehensive patient data for tailored medical strategies.
- Significant potential exists for precision medicine to enhance diagnosis and treatment of prevalent DGBIs.
- Current implementation in DGBIs is minimal, necessitating strategic development.
Conclusions:
- Precision medicine offers a promising avenue for advancing the care of DGBIs.
- Overcoming limitations and developing strategic implementation are crucial for realizing precision medicine's benefits in DGBIs.
- Further research and clinical integration are needed to harness precision medicine for improved DGBI patient outcomes.
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