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Anti-VGLUT2 autoantibodies associated with post-COVID neurocognitive dysfunction: a case report
Jeyanthan Charles James1, Bianca Teegen2, Thivya Pakeerathan1
1Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
Frontiers in Immunology
|February 2, 2026
Summary
Post-COVID-19 syndrome (PCS) may involve VGLUT2 autoantibodies, potentially explaining fatigue and cognitive issues. Further research is needed to confirm this link in larger patient groups.
Area of Science:
- Neurology
- Immunology
- Infectious Diseases
Background:
- Post-COVID-19 syndrome (PCS) frequently presents with debilitating fatigue and cognitive dysfunction.
- The precise pathophysiological mechanisms underlying PCS remain largely unknown.
- Persistent neurological symptoms after SARS-CoV-2 infection warrant investigation into potential autoimmune components.
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