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Developing Normative Reference Values for Nerve Conduction Studies Using Electrophysiological Parameters in the

S K Mahbub Alam1, Sahariar Hossain Siddik1, M Ferdousi2

  • 1Department of Neurology, Bangladesh Medical University, Dhaka, Bangladesh.

Neurology Research International
|February 2, 2026
PubMed
Summary

This study establishes nerve conduction study reference values for Bangladeshis. These population-specific findings aid in diagnosing nerve disorders more accurately within the region.

Keywords:
nerve conduction studynormal valuesnormative datareference values

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Area of Science:

  • Neurology
  • Clinical Neurophysiology

Background:

  • Nerve conduction studies (NCS) are crucial for diagnosing peripheral nerve disorders.
  • Existing NCS reference values often lack ethnic and geographic specificity.
  • Establishing population-specific norms is essential for accurate clinical interpretation.

Purpose of the Study:

  • To determine normative reference values for nerve conduction studies in a healthy Bangladeshi population.
  • To compare these values with international data and identify significant differences.
  • To provide essential data for Bangladeshi neurophysicians to improve diagnostic accuracy.

Main Methods:

  • Recruitment of 258 healthy Bangladeshi subjects, stratified by age and sex.
  • Comprehensive assessment of motor and sensory nerve conduction in upper and lower limbs.
  • Application of ordinary least square (OLS) regression for data analysis.

Main Results:

  • Normative values for the left median motor nerve (e.g., distal latency, amplitude, conduction velocity) were established.
  • Normative values for the left median sensory nerve (e.g., latency, amplitude, velocity) were determined.
  • Significant differences were observed when compared to existing international nerve conduction study data.

Conclusions:

  • The study provides the first population-specific reference values for NCS in Bangladesh.
  • These normative data will enhance the diagnostic accuracy of nerve conduction abnormalities.
  • Implementation of these findings will support more effective diagnosis and treatment of nerve disorders in Bangladesh.