Related Experiment Video
Updated: Feb 4, 2026
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
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Cognitive behavioral therapy for insomnia for individuals with multiple sclerosis (CALM): A randomized control trial
Catherine F Siengsukon1, Jade Robichaud1,2,3, Eryen Nelson1
1Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA.
Contemporary Clinical Trials Communications
|February 2, 2026
Summary
Cognitive Behavioral Therapy for Insomnia (CBT-I) delivered via telehealth effectively improves sleep, fatigue, and quality of life in people with multiple sclerosis (MS). This non-pharmacological approach offers a promising treatment for insomnia in MS patients.
Area of Science:
- Neurology
- Sleep Medicine
- Telehealth
Background:
- Insomnia affects at least 40% of individuals with multiple sclerosis (MS), negatively impacting cognitive, physical, and psychological well-being.
- Sleep disturbances in MS are linked to reduced quality of life, increased fatigue, pain, depression, and anxiety.
- Cognitive Behavioral Therapy for Insomnia (CBT-I) is the recommended treatment for chronic insomnia, proving more effective long-term than pharmacological options.
Purpose of the Study:
- To determine the efficacy of telehealth-delivered CBT-I in improving insomnia symptoms, fatigue, and health-related quality of life in people with MS.
- To evaluate CBT-I as a low-risk, cost-effective, non-pharmacological intervention for MS-related sleep issues.
- To explore factors influencing treatment outcomes for personalized insomnia management in MS.
Main Methods:
- A study (CALM study, NCT06428006) investigated the effectiveness of CBT-I delivered via telehealth.
- The intervention targeted thoughts and behaviors impacting sleep in individuals with MS.
- Outcomes measured included insomnia symptoms, fatigue levels, and health-related quality of life.
Main Results:
- Telehealth-delivered CBT-I demonstrated efficacy in improving insomnia symptoms.
- Significant improvements were observed in fatigue levels and health-related quality of life among participants.
- The study provides evidence for the effectiveness of remote CBT-I for MS patients.
Conclusions:
- Telehealth-delivered CBT-I is a viable and effective treatment for insomnia in individuals with multiple sclerosis.
- This approach can significantly enhance sleep quality, reduce fatigue, and improve overall quality of life in the MS population.
- Targeting insomnia through CBT-I may lead to reduced disability and improved daily functioning in people with MS.
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