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Updated: Feb 4, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Liposome-based delivery of DNA aptamers to inhibit erythromycin methyltransferase-mediated antibiotic resistance
Swagata Patra1, Damini Sahu1, Leena L Badgujar1
1Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India. swagata1012@gmail.com.
Abstract:
Resistance to macrolides, lincosamides, and the streptogramin B class of antibiotics is caused by the methylation activity of erythromycin methyltransferases. Here, we encapsulated DNA aptamers inhibiting Erm into specifically designed liposomes to enhance stability, uptake, and delivery properties. This delivery system restores erythromycin sensitivity in resistant Staphylococcus aureus, offering a promising therapeutic platform against MDR bacteria.
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