Cascade of Cardiac Rehabilitation Referral, Enrollment, and Completion and Its Major Predictors in a Large Hospital

Lena Mathews1,2,3,4, Siyu Zou5,4, Lisa R Yanek6

  • 1Division of Cardiology (Drs Mathews, Blumenthal, Stewart, Ndumele, and Matsushita), Johns Hopkins University, Baltimore, Maryland.

Insights

Cardiac rehabilitation (CR) is underused, with significant gaps in referral, enrollment, and completion. Identifying demographic and system factors hindering CR use is crucial for improving secondary prevention strategies.

Area of Science:

  • Cardiology
  • Public Health
  • Health Services Research

Background:

  • Cardiac rehabilitation (CR) is a vital secondary prevention strategy for patients with cardiac events.
  • Despite its proven benefits, CR remains significantly underutilized in clinical practice.
  • Understanding implementation gaps is essential for optimizing patient outcomes.

Purpose of the Study:

  • To identify specific points in the CR care cascade where implementation gaps occur.
  • To examine demographic and health system characteristics associated with CR utilization.
  • To inform strategies for increasing CR referral, enrollment, and completion.

Main Methods:

  • Analysis of electronic health records from a large academic health system (2017-2019).
  • Inclusion of adult patients hospitalized with a cardiac event requiring CR.
  • Use of mixed-effects logistic regression to assess factors associated with CR referral, enrollment, and completion.

Main Results:

  • Only 25% of eligible patients were referred to CR, with 29% enrolling and 21% completing the program.
  • Lower CR utilization was associated with Black race, female sex, and discharge from non-cardiology services.
  • Post-discharge cardiology follow-up visits were linked to higher CR referral rates.

Conclusions:

  • Significant bottlenecks exist at each stage of the CR care cascade, particularly at completion.
  • Demographic and health system factors contribute to disparities in CR utilization.
  • Targeted interventions addressing these identified barriers are needed to enhance CR adoption and effectiveness.
Abstract

Related Concept Videos

Hospitals-II00:59

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...
1.2K
Hospitals-I01:28

Hospitals-I

Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.6K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
53.6K
Rab Cascades01:25

Rab Cascades

Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
3.6K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
18.5K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
8.4K