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Updated: Feb 4, 2026
06:15
A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
Published on: July 15, 2025
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Kidney function and five types of psychiatric traits/disorders: a bidirectional mendelian randomisation study
Summary
Psychiatric disorders significantly impact kidney function, with bidirectional causality observed. Lifestyle factors like BMI and smoking mediate these complex relationships, offering potential intervention targets.
Area of Science:
- Genetics
- Psychiatry
- Nephrology
Background:
- Psychiatric disorders and kidney dysfunction frequently co-occur.
- The precise causal relationships between these conditions are not well understood.
Purpose of the Study:
- To investigate the bidirectional causal relationships between psychiatric traits/disorders and kidney function.
- To explore the mediating role of lifestyle factors in these associations.
Main Methods:
- Utilized a bidirectional Mendelian randomization (MR) study design.
- Employed genetic instruments from large-scale Genome-Wide Association Studies (GWAS).
- Applied Inverse Variance Weighted (IVW) analysis and sensitivity methods, including mediation analysis.
Main Results:
- Psychiatric disorders had more pronounced causal effects on kidney impairment than vice versa.
- Specific associations found: anxiety/MDD reduced creatinine, anxiety increased uric acid, schizophrenia showed bidirectional links with uric acid/BUN, and several disorders elevated eGFRcrea.
- Anxiety, neuroticism, and bipolar disorder were linked to increased risk of acute kidney injury (AKI) and chronic kidney disease (CKD).
- BMI, education, alcohol consumption, and smoking significantly mediated the pathways from psychiatric traits to renal function.
Conclusions:
- Established bidirectional genetic causality between psychiatric disorders and kidney function.
- Highlighted that psychiatric conditions exert stronger causal effects on kidney impairment.
- Identified modifiable lifestyle factors as potential targets for prevention and intervention strategies.
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