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Related Experiment Video

Updated: Jun 16, 2026

Preparation of Functional Silica Using a Bioinspired Method

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

Bioinspired silk-catechol-enzyme co-assemblies as jigsaw-designed conformation-locking bioactive-biocatalytic

Jiahui Hao¹, Yuling Zhang¹, Haiying Luo¹

¹School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107, PR China.

Bioactive Materials

|June 15, 2026

Summary

This summary is machine-generated.

We developed a versatile platform using silk fibroin and protocatechualdehyde to immobilize enzymes, enhancing their stability and enabling diverse bio-applications. This adaptable system ensures enzymes retain activity and function in various formats.

Keywords:

Antibacterial Bioinspired self-assembly Biological functionality Multifunctional platform Surface functionalization

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Designing Silk-silk Protein Alloy Materials for Biomedical Applications

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Published on: August 13, 2014

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Last Updated: Jun 16, 2026

Preparation of Functional Silica Using a Bioinspired Method

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Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

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Designing Silk-silk Protein Alloy Materials for Biomedical Applications

Designing Silk-silk Protein Alloy Materials for Biomedical Applications

Published on: August 13, 2014

Area of Science:

Biomaterials Engineering
Enzyme Immobilization
Sustainable Catalysis

Background:

Soluble enzymes are costly and unstable for industrial use.
Existing enzyme immobilization methods lack adaptability and broad material compatibility.
A need exists for robust platforms that preserve enzyme structure and function.

Purpose of the Study:

To create a facile and general platform for enzyme immobilization.
To enhance enzyme stability, conformation, and functional adaptability.
To develop bioactive materials for diverse bio-applications.

Main Methods:

Co-assembly of silk fibroin (SF), protocatechualdehyde (PA), and enzymes.
Utilizing mussel-inspired PA for enzyme conformational locking and anchoring.
Programming assemblies into coatings, films, hydrogels, and nanoparticles.

Main Results:

Achieved exceptional enzyme stability (20 cycles at 50°C, 47.7% activity after 1-year storage).
Demonstrated universal adhesion to various surfaces (solids, MOFs, liquid metals).
Enabled diverse functionalities including biomimetic mineralization, antioxidation, and antibacterial activity.

Conclusions:

The modular SF-PA platform offers a versatile blueprint for robust, catalytically bioactive materials.
This adaptable system significantly enhances enzyme stability and broadens immobilization possibilities.
The platform shows promise for advanced bio-applications, including improved biocompatibility and anti-inflammatory effects.