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Molecular classification of radiation-induced meningiomas.

Yosef Ellenbogen1,2,3, Vikas Patil1,3, Alexander P Landry1,2,3

  • 1MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada.

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|February 2, 2026
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Summary
This summary is machine-generated.

Radiation-induced meningiomas (RIMs) predominantly align with the hypermetabolic molecular group, showing distinct genomic instability and metabolic pathway activation compared to sporadic tumors.

Keywords:
DNA methylationRadiation-induced meningiomamolecular classificationmolecular subtypes

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Area of Science:

  • Neuro-oncology
  • Genomics
  • Epigenomics

Background:

  • Radiation-induced meningiomas (RIMs) are aggressive tumors, a late complication of cranial irradiation.
  • Sporadic meningiomas are classified into four molecular groups, but RIMs lack similar molecular characterization.

Purpose of the Study:

  • To classify Radiation-induced meningiomas (RIMs) using the established methylation-based classification of sporadic meningiomas.
  • To investigate the molecular and clinical characteristics of RIMs in comparison to sporadic meningiomas.

Main Methods:

  • DNA methylation data from 20 RIMs were integrated with a reference cohort of 121 sporadic meningiomas.
  • Supervised machine learning was used for molecular subgroup assignment.
  • Copy-number alterations and pathway enrichment analyses were performed.

Main Results:

  • 70% of RIMs were classified into the hypermetabolic molecular subtype.
  • RIMs exhibited DNA hypomethylation enriched for metabolic and biosynthetic pathways.
  • Widespread chromosomal instability, including 22q loss, was observed in RIMs.

Conclusions:

  • Radiation-induced meningiomas (RIMs) predominantly belong to the hypermetabolic molecular group.
  • RIMs display a distinct molecular profile characterized by metabolic activation and genomic instability compared to sporadic meningiomas.