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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
The TAK-003 story: key decisions that shaped development of a tetravalent dengue vaccine
Ian Escudero1, Dieter Gniel2, Shibadas Biswal3
1Takeda Vaccines, Inc., Boston, MA, USA. ian.escudero@takeda.com.
Abstract:
The approved, live-attenuated tetravalent dengue vaccine TAK-003 has undergone extensive preclinical and clinical assessment. This review provides an overview of the rationale for some key decisions made during TAK-003 development. These include decisions around vaccine composition, assessment of factors that may be associated with the safety of live-attenuated viral vaccines, dosing schedule, immunogenicity assessments, and design of the pivotal phase 3 efficacy study.
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