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Updated: Feb 4, 2026

The Fastest Western in Town: A Contemporary Twist on the Classic Western Blot Analysis
Published on: February 5, 2014
Stereoselective Synthesis of the Western Fragment of Vancoresmycin
Max Schönenbroicher1, Maximilian Seul1, Simon Morgenschweis1
1Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, D-53121 Bonn, Germany.
Abstract:
The synthesis of the western fragment of vancoresmycin was accomplished in a highly modular and stereoselective manner. Central to this strategy was a modified Cu-catalyzed β-boration protocol for α,β-unsaturated enones, which enabled convergent construction of complex, densely functionalized polyketide architectures with high stereocontrol. Application to a structurally demanding fragment highlighted its potential as a general tool for 1,3-diol construction. In addition, NMR comparison confirmed the stereochemical assignment of the western part of vancoresmycin.
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