The role of necroptosis in adiposity-based chronic disease (ABCD): A review

Recently, as the obesity rate continues to rise and people's understanding of obesity deepens, adiposity-based chronic disease has appeared in people's view as a new obesity diagnostic term. As an endocrine, nutritional and metabolic disease, the mechanism of obesity is because energy intake exceeds energy consumption, resulting in excessive accumulation of body fat and abnormal weight, which can lead to a series of complications such as insulin resistance, diabetes mellitus, atherosclerosis (AS) and nonalcoholic fatty liver disease (NAFLD). In the last decade, a type of regulated and genetically controlled necrosis has emerged known as necroptosis. Necroptosis differs from non-immunogenic apoptosis in that it releases of cell contents and cytokines, which triggers an inflammatory response in adjacent tissues. Studies have shown that necroptosis is involved in the pathogenesis of obesity and its complications and that inhibition of necroptosis may reduce the progression of obesity-induced disease. In this paper, we discuss the role of necroptosis in adiposity-based chronic disease as well as the relationship between necroptosis and other cell death modes from the point of view of the mechanism of necroptosis.