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Functional Brain Activity Associated With Intermittent Rhythmic Delta/Theta Activity: A Transdiagnostic

Bernd Feige1, Katharina von Zedtwitz1, Isabelle Matteit1

  • 1Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Biological Psychiatry Global Open Science
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Summary
This summary is machine-generated.

Intermittent rhythmic delta/theta activity (IRDA/IRTA) in EEG is linked to brain changes in neuropsychiatric disorders. This study used EEG-fMRI to map these brain regions in autoimmune psychiatric syndromes (APS) and borderline personality disorder (BPD).

Keywords:
Autoimmune psychosisBorderline personality disorderEEG slowingEpilepsyExcitationMREG

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Intermittent rhythmic delta/theta activity (IRDA/IRTA) detected via electroencephalography (EEG) is associated with the pathophysiology of neuropsychiatric disorders.
  • A combined EEG and functional magnetic resonance imaging (fMRI) approach is valuable for investigating brain function in these conditions.

Purpose of the Study:

  • To characterize brain regions functionally correlated with IRDA/IRTA using a combined EEG-fMRI approach.
  • To investigate these correlations in transdiagnostic groups including patients with suspected autoimmune psychiatric syndromes (APS) and borderline personality disorder (BPD), as well as healthy controls (HC).

Main Methods:

  • Utilized 135 EEG-fMRI datasets from 33 APS patients, 59 BPD patients, and 43 HC participants.
  • Employed ultrafast MR encephalography and AFNI software for fMRI analysis.
  • Applied independent component analysis and algorithmic detection to isolate IRDA/IRTA events from artifacts.

Main Results:

  • Identified 11 consensus brain regions correlated with IRDA/IRTA across all groups, with 5 showing increased activity and 6 showing reduced activity.
  • The APS group exhibited 5 additional clusters with reduced activity.
  • The BPD group showed one additional cluster with increased activity.

Conclusions:

  • IRDA/IRTA is associated with brain activity changes in fronto-centro-temporal regions, resembling the salience network.
  • Disease-specific brain activity changes related to IRDA/IRTA were identified in APS and BPD patients.