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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Sustainable production of glutaric acid in microbial cell factories: Current advances and future prospects
Jie Liu1,2, Dan Mei1, Xuan-Jun Zhang1
1School of Biological and Food Engineering, Anhui Polytechnic University, 18Beijing Middle Road, WuHu, 241000, People's Republic of China.
Abstract:
Glutaric acid is a significant C5 dicarboxylic acid, extensively utilized in the chemical industry, medicine, and biomaterials. In recent years, the advancement of synthetic biology and metabolic engineering has rendered microbial production of glutaric acid a sustainable alternative to conventional chemical synthesis. This study reviews recent advancements in glutaric acid biosynthesis, primarily concentrating on the design of biosynthetic pathways and metabolic engineering strategies for the development of engineered strains. The utilization of systems biology technologies in the development of the glutaric acid biosynthetic pathway is examined. This study outlines the issues associated with glutaric acid biosynthesis and its prospective developmental trajectory, intending to offer theoretical insights and technological guidance for the sustainable production of glutaric acid and related fine chemicals.
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