Related Experiment Video
Updated: Feb 5, 2026
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
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[68Ga]Ga-FAPI Surpasses [18F]FDG in Pancreatic Adenosquamous Carcinoma Restaging.
Ahmed Saad Abdlkadir1, Hussam Haddad2, Issa Mohamad3
1Departments of Nuclear Medicine and PET/CT.
Clinical Nuclear Medicine
|February 3, 2026
Summary
Pancreatic adenosquamous carcinoma (PASC) is aggressive. [68Ga]Ga-FAPI PET/CT is superior to [18F]FDG PET/CT for detecting PASC recurrence after initial treatment.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiochemistry
Background:
- Pancreatic adenosquamous carcinoma (PASC) is a rare and aggressive exocrine neoplasm.
- Early diagnosis and accurate staging are critical for effective management of PASC.
- Positron emission tomography/computed tomography (PET/CT) plays a vital role in cancer imaging.
Purpose of the Study:
- To evaluate the utility of [68Ga]Ga-FAPI PET/CT in detecting recurrent pancreatic adenosquamous carcinoma.
- To compare the efficacy of [68Ga]Ga-FAPI PET/CT with [18F]FDG PET/CT in identifying PASC recurrence.
- To highlight the potential of novel imaging agents in managing aggressive malignancies.
Main Methods:
- Case report of a 33-year-old female patient diagnosed with stage IV PASC.
- Baseline [18F]FDG PET/CT for staging and treatment planning.
- Follow-up [18F]FDG PET/CT after FOLFIRINOX chemotherapy.
- Restaging using both [18F]FDG PET/CT and [68Ga]Ga-FAPI PET/CT.
Main Results:
- Initial [18F]FDG PET/CT accurately staged the PASC.
- Complete metabolic resolution was observed on follow-up [18F]FDG PET/CT after chemotherapy.
- Disease relapse occurred within 5 months, undetected by [18F]FDG PET/CT.
- [68Ga]Ga-FAPI PET/CT successfully identified both local and metastatic PASC recurrences.
Conclusions:
- [68Ga]Ga-FAPI PET/CT demonstrates superior sensitivity for detecting recurrent pancreatic adenosquamous carcinoma compared to [18F]FDG PET/CT.
- This finding suggests [68Ga]Ga-FAPI PET/CT may be a valuable tool for surveillance and restaging of PASC.
- Novel imaging agents like [68Ga]Ga-FAPI hold promise for improving the management of rare and aggressive cancers.
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