Three new 14-noreudesmane-type sesquiterpenoids from the roots of Hippophae rhamnoides
Fatima Abdurrahman Galadanchi1,2,3, Polina Lopukhina1,2,3, Sisi Bai1,2,3
1Guangdong Provincial Key Laboratory of Applied Botany and Key Laboratory of National Forestry and Grassland Administration On Plant Conservation and Utilization in Southern China, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China.
Abstract:
Hippophae rhamnoides L. (Elaeagnaceae), commonly known as sea buckthorn, is a medicinal plant valued for its diverse bioactive constituents and broad therapeutic potential. Phytochemical investigation of its roots led to the isolation of three new 14-noreudesmane-type sesquiterpenoids (1-3), together with sixteen known compounds (4-19). Their structures and absolute configurations were determined using comprehensive spectroscopic analyses and quantum chemical computations of electronic circular dichroism (ECD) spectra and 13C NMR shifts. Three new sesquiterpenoids (1-3) were tested for their antioxidant, anti-inflammatory, antibacterial, and α-glucosidase inhibitory activities. Unfortunately, none exhibited significant activity under the tested conditions. Among the isolated known compounds, all those displaying α-glucosidase inhibitory and antibacterial activities are pentacyclic triterpenoids. Hippophamide (17) showed significant DPPH and ABTS radical-scavenging activity. These results enriched the chemical profile of H. rhamnoides roots.
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