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Home
Bismuth Bicycles.

Home
Bismuth Bicycles.

Related Experiment Video

Seedless Growth of Bismuth Nanowire Array via Vacuum Thermal Evaporation

Seedless Growth of Bismuth Nanowire Array via Vacuum Thermal Evaporation

Published on: December 21, 2015

Bismuth Bicycles.

Saan Voss^1,2, Amin Sagar², Arnaud Tiberghien²

¹Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.

Journal of Peptide Science : an Official Publication of the European Peptide Society

|February 4, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Bicyclic peptides offer therapeutic advantages by mimicking antibodies with small molecule synthesis. A new class of bismuth bicyclic peptides expands therapeutic possibilities at the inorganic chemistry-biology interface.

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Published on: August 22, 2018

Area of Science:

Medicinal Chemistry
Biotechnology
Inorganic Chemistry

Background:

Bicyclic peptides combine antibody-like affinity and specificity with small molecule synthetic ease.
Phage display facilitates the discovery of high-affinity bicyclic peptides for diverse protein targets.
Traditional bicyclic peptide generation involves reacting three cysteines with a C3-symmetric alkylating agent.

Purpose of the Study:

To review the discovery and evolution of bicyclic peptides as therapeutics.
To highlight the emergence of bismuth-based bicyclic peptides.
To explore the future applications of bismuth bicycle molecules in medicine.

Main Methods:

Phage display technology for library generation.
Chemical modification of peptides using C3-symmetric agents.

Exploration of inorganic scaffolds, specifically bismuth, for peptide cyclization.

Main Results:

Bicyclic peptides serve as effective protein mimetics, binding challenging protein surfaces.
A novel class of bicyclic peptides utilizing bismuth has been developed.
This innovation bridges inorganic chemistry and biology for novel therapeutic design.

Conclusions:

Bicyclic peptides represent a promising next-generation therapeutic modality.
Bismuth bicyclic peptides open new avenues in drug discovery by expanding chemical space.
Further research into bismuth bicycle molecules holds significant therapeutic potential.