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Updated: Feb 5, 2026

Seedless Growth of Bismuth Nanowire Array via Vacuum Thermal Evaporation

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Published on: December 21, 2015

Bismuth Bicycles.

Saan Voss^1,2, Amin Sagar², Arnaud Tiberghien²

¹Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.

Journal of Peptide Science : an Official Publication of the European Peptide Society

|February 4, 2026

Summary

This summary is machine-generated.

Bicyclic peptides offer therapeutic advantages by mimicking antibodies with small molecule synthesis. A new class of bismuth bicyclic peptides expands therapeutic possibilities at the inorganic chemistry-biology interface.

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Published on: August 22, 2018

Area of Science:

Medicinal Chemistry
Biotechnology
Inorganic Chemistry

Background:

Bicyclic peptides combine antibody-like affinity and specificity with small molecule synthetic ease.
Phage display facilitates the discovery of high-affinity bicyclic peptides for diverse protein targets.
Traditional bicyclic peptide generation involves reacting three cysteines with a C3-symmetric alkylating agent.

Purpose of the Study:

To review the discovery and evolution of bicyclic peptides as therapeutics.
To highlight the emergence of bismuth-based bicyclic peptides.
To explore the future applications of bismuth bicycle molecules in medicine.

Main Methods:

Phage display technology for library generation.
Chemical modification of peptides using C3-symmetric agents.
Exploration of inorganic scaffolds, specifically bismuth, for peptide cyclization.

Main Results:

Bicyclic peptides serve as effective protein mimetics, binding challenging protein surfaces.
A novel class of bicyclic peptides utilizing bismuth has been developed.
This innovation bridges inorganic chemistry and biology for novel therapeutic design.

Conclusions:

Bicyclic peptides represent a promising next-generation therapeutic modality.
Bismuth bicyclic peptides open new avenues in drug discovery by expanding chemical space.
Further research into bismuth bicycle molecules holds significant therapeutic potential.