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Association between prediabetes and the risk of atrial fibrillation: a systematic review and meta-analysis
Yongchao Li1,2, Ju Deng3, Li Li1,3
1Jinan University, Guangzhou, China.
Insights
Prediabetes, a precursor to diabetes, is linked to a higher risk of atrial fibrillation (AF). Early detection and management of prediabetes may help prevent AF development.
Area of Science:
- Cardiology
- Metabolic Health
- Epidemiology
Background:
- Atrial fibrillation (AF) is a common cardiac arrhythmia contributing to significant morbidity and mortality.
- Diabetes is a known risk factor for AF, but the association with prediabetes remains unclear.
- Understanding the AF risk in prediabetes is crucial for early intervention and prevention strategies.
Purpose of the Study:
- To systematically review and meta-analyze cohort studies investigating the association between prediabetes and incident atrial fibrillation.
- To quantify the risk of AF in individuals with prediabetes compared to normoglycemic controls.
Main Methods:
- A comprehensive search of PubMed, Embase, and Web of Science databases was conducted.
- Included were cohort studies reporting adjusted hazard ratios for AF in adults with prediabetes.
- Random-effects models were used for meta-analysis, with heterogeneity assessed via I² statistic and subgroup analyses performed.
Main Results:
- Twelve cohort studies with over 15 million participants revealed a statistically significant increased risk of AF in individuals with prediabetes (HR: 1.20; 95% CI: 1.08-1.35).
- Substantial heterogeneity was observed, with a numerically stronger association noted in Asian populations, though this requires cautious interpretation.
- Sensitivity and subgroup analyses confirmed the association, with limited evidence of publication bias.
Conclusions:
- Prediabetes is associated with an elevated risk of atrial fibrillation across various populations.
- While the study design indicates association, not causation, these findings highlight the potential for AF prevention through early prediabetes management.
- Identifying and managing prediabetes may offer a critical window for cardiovascular risk reduction.
Background:
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major contributor to morbidity and mortality. Although diabetes is a well-established risk factor for AF, the role of prediabetes-a modifiable metabolic condition-remains uncertain. Clarifying this relationship may help identify individuals at risk and guide early preventive strategies.
Methods:
We performed a systematic review and meta-analysis of cohort studies identified through PubMed, Embase, and Web of Science databases up to November 21, 2025. Studies reporting adjusted hazard ratios for incident AF in adults with prediabetes compared with normoglycemic controls were included. Pooled estimates were calculated using random-effects models, and heterogeneity was assessed using the I² statistic. Prespecified subgroup analyses explored variations by definition of prediabetes, geographic region, follow-up duration, age, and sex. Publication bias was evaluated using Egger's and Begg's tests.
Results:
Twelve independent datasets from 11 cohort studies, including over 15 million participants and 277,164 incident AF cases, were analyzed. Prediabetes was associated with a modest but statistically significant increased risk of AF (pooled hazard ratio: 1.20; 95% confidence interval: 1.08-1.35), with substantial heterogeneity. Sensitivity analyses showed consistent results. Subgroup analyses indicated a numerically stronger association in Asian populations than in Europe and North America; this finding should be interpreted cautiously given heterogeneity and limited studies per subgroup. Other subgroup analyses were broadly consistent, and overall evidence of publication bias was limited.
Conclusion:
Prediabetes is associated with increased AF risk across diverse populations. Given the observational design, these findings indicate association rather than causation. Early identification and management of prediabetes may provide an opportunity for AF prevention.
Systematic Review Registration:
https://www.crd.york.ac.uk/prospero/, identifier CRD420251233423.
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