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INTRAOCULAR PRESSURE OF PREMATURE NEWBORNS - A SYSTEMATIC REVIEW WITH META-ANALYSIS

Kalina Trifonova1, Kiril Slaveykov1, Hristo Mumdzhiev2

  • 1Department of Ophthalmology, University Hospital, Stara Zagora, Bulgaria.

Acta Clinica Croatica
|February 4, 2026
PubMed

Insights

Intraocular pressure (IOP) in premature newborns is higher than in full-term infants, ranging from 10 to 29 mmHg. Central corneal thickness also decreases with maturation and correlates with IOP.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Pediatrics

Background:

  • Intraocular pressure (IOP) in premature newborns differs significantly from full-term infants and adults.
  • Variations in IOP ranges are influenced by measurement techniques and analytical methods.

Purpose of the Study:

  • To systematically review and analyze current literature on IOP values in premature newborns.
  • To establish typical IOP ranges and identify influencing factors in this population.

Main Methods:

  • Systematic literature review.
  • Meta-analysis of existing studies on premature newborn IOP.
  • Analysis of factors affecting IOP measurements, including central corneal thickness.

Main Results:

  • Mean IOP in premature newborns ranges from 10 to 29 mmHg.
  • Premature newborns exhibit higher mean IOP compared to full-term newborns.
  • Central corneal thickness is a significant factor influencing IOP and declines with newborn maturation, showing a probable correlation with IOP.

Conclusions:

  • Premature newborns have distinct IOP ranges, generally higher than full-term infants.
  • Central corneal thickness is a key factor in IOP measurement variability and changes with infant development.
  • Further research with larger, well-defined cohorts is necessary to fully understand IOP dynamics in premature infants.

Keywords:
Central corneal thicknessInfantsIntraocular pressurePreterm infants

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