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Updated: Feb 5, 2026

Forward Genetic Approaches in Chlamydia trachomatis
Published on: October 23, 2013
Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity
Filomeno Coelho da Silva1, Kazutomo Yokoya1, Rana Hussain1
1Virus Reference Department, Public Health Microbiology Division, UK Health Security Agency, London, United Kingdom.
Abstract:
Chlamydia trachomatis (Ct) is a sexually transmitted infection (STI) linked to ectopic pregnancy, infertility, invasive lymphogranuloma venereum (LGV), and the blinding disease trachoma. STI, LGV, and trachoma are associated with disease-specific Ct genovars. Serology is an important surveillance tool for estimating exposure, but the impact of genome variation on the antigenicity of Ct proteins is unclear. Two-dimensional antigenicity profiling of Pgp3 antigens representing LGV, STI, and trachoma demonstrated differential antigenicity using antigen-specific murine sera, but geometric distances were not considered significant (≤2-fold) for human infection sera. Pgp3 should be considered a single serotype for the purposes of Ct serosurveillance.
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