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Related Concept Videos

Bernoulli's Principle: Applications01:17

Bernoulli's Principle: Applications

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There are many devices and situations in which fluid flows at a constant height and so can be analyzed using Bernoulli's principle. These devices include, but are not limited to, entrainment devices and fluid flow measuring devices.
Entrainment devices use a high fluid speed to create low pressures and, thus, entrain one fluid into another. Some examples of these devices are given below:
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Design Example: Application of Archimedes' Principle01:11

Design Example: Application of Archimedes' Principle

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Archimedes' principle is fundamental in analyzing the buoyant force and stability of floating bodies. In this example, a wooden block with a rectangular section floats in seawater. Based on the block's dimensions, its specific gravity and the specific weight of seawater are used to find the volume of water displaced and the center of buoyancy.
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The Uncertainty Principle04:08

The Uncertainty Principle

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Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that there is a fundamental limit to how accurately one can measure both a particle’s position and its momentum simultaneously. The more accurate the measurement of the momentum of a particle is known, the less accurate the position at that time is known and vice versa. This is what is now called the Heisenberg uncertainty principle. He...
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Hardy-Weinberg Principle01:49

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Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
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The Pauli Exclusion Principle03:06

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The arrangement of electrons in the orbitals of an atom is called its electron configuration. We describe an electron configuration with a symbol that contains three pieces of information:
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The Aufbau Principle and Hund's Rule03:02

The Aufbau Principle and Hund's Rule

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To determine the electron configuration for any particular atom, we can build the structures in the order of atomic numbers. Beginning with hydrogen, and continuing across the periods of the periodic table, we add one proton at a time to the nucleus and one electron to the proper subshell until we have described the electron configurations of all the elements. This procedure is called the aufbau principle, from the German word aufbau (“to build up”). Each added electron occupies the...
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SlipChip: from principle to applications.

Yang Luo1, Weijie Yuan2, Sujin Jung1

  • 1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China. feng.shen@sjtu.edu.cn.

Lab on a Chip
|February 4, 2026
PubMed
Summary
This summary is machine-generated.

The SlipChip is a microfluidic platform enabling precise fluid control via sliding plates, simplifying complex assays. This versatile technology offers portability and cost-effectiveness for diverse applications in research and diagnostics.

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Area of Science:

  • Biotechnology and Biomedical Engineering
  • Microfluidics and Lab-on-a-Chip Technology

Background:

  • Microfluidic platforms are crucial for precise fluid handling in various scientific disciplines.
  • Conventional microfluidics often require complex external components like pumps and valves.
  • The SlipChip offers a novel approach to microfluidic control through mechanical reconfiguration.

Purpose of the Study:

  • To review the fluidic principles, fabrication methods, and diverse applications of the SlipChip platform.
  • To highlight the advantages of SlipChip over conventional microfluidic systems.
  • To discuss current limitations and future advancements in SlipChip technology.

Main Methods:

  • Review of existing literature on SlipChip design, principles, and applications.
  • Analysis of fluidic reconfiguration mechanisms induced by sliding plates.
  • Examination of material considerations for SlipChip fabrication.

Main Results:

  • SlipChip enables precise fluid aliquoting, mixing, and partitioning through simple sliding operations.
  • Applications span nucleic acid assays, protein analysis, single-cell studies, and materials synthesis.
  • Advantages include simple manipulation, on-chip reagent preloading, portability, and cost-effective fabrication.

Conclusions:

  • SlipChip is a robust and accessible microfluidic platform with significant potential for research and clinical diagnostics.
  • Future developments in materials, automation, and AI will enhance reliability and enable autonomous workflows.
  • The technology is poised to expand its role in systems biology, diagnostics, and personalized medicine.