Related Experiment Video
Updated: Feb 6, 2026
08:36
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
1.2K
Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control,
Aesthetic Surgery Journal
|February 4, 2026
Summary
Poly-L-lactic acid (PLLA) effectively treats temple hollowing, a common aesthetic concern. This study shows PLLA facial filler provides significant, lasting improvement and high patient satisfaction with a strong safety profile.
Area of Science:
- Aesthetic medicine and dermatology
- Injectable soft-tissue fillers
- Regenerative aesthetics
Background:
- Temple hollowing is a frequent aesthetic concern.
- Current treatments include autologous fat grafting and hyaluronic acid fillers.
- Poly-L-lactic acid (PLLA) offers gradual, collagen-mediated volumization for soft-tissue augmentation.
Purpose of the Study:
- To assess the efficacy and safety of a PLLA facial filler for temple hollowing.
- To evaluate PLLA as a treatment for temporal augmentation.
Main Methods:
- A randomized, no-treatment control, evaluator-blinded, multicenter clinical trial.
- 174 participants with moderate to severe temple hollowing were randomized 2:1.
- Efficacy assessed via Allergan Temple Hollowing Scale (ATHS), Global Aesthetic Improvement Scale (GAIS), 3D volume, and participant satisfaction over 12 months.
Main Results:
- 96.5% of PLLA-treated participants showed at least 1-grade improvement in ATHS at 6 months versus 0% in controls (P < 0.0001).
- Significant improvements in ATHS, GAIS, and temporal volume were sustained up to 12 months.
- High participant satisfaction and an excellent safety profile with no therapy-related adverse events were reported.
Conclusions:
- PLLA facial filler is an effective treatment for temple hollowing.
- PLLA provides significant aesthetic enhancement and volume restoration for up to 12 months.
- The PLLA filler demonstrated a favorable safety profile in this study.
More Related Videos
04:40The Cultivation, Growth, and Viability of Lactic Acid Bacteria: A Quality Control Perspective
Published on: June 16, 2022
9.4K
08:53Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
1.8K
Related Concept Videos
02:07Blind Procedures
13.5K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.5K
01:29Additives and Fillers in Concrete
355
Additives and fillers are integral to enhancing the properties of concrete. Pozzolans and blast-furnace slag are additives or admixtures due to their reactions with calcium hydroxide released during cement hydration. Fillers, which are finely ground and similar in fineness to Portland cement, improve concrete attributes such as workability density, and reduce capillary bleeding or cracking. Some fillers possess hydraulic properties or participate in benign reactions within the cement paste.
The...
The...
355
01:11Blinding
4.0K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
4.0K
01:20Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs
250
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
250
01:28Survey Safety
410
Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
410
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
474
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
474