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Updated: Feb 6, 2026

Evaluation of Blood Lactate and Plasma Insulin During High-intensity Exercise by Antecubital Vein Catheterization
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Lactate-driven mitochondrial pretenders hijack hippocampal function after excessive exercise.

Filip J Larsen1

  • 1Department of Physiology, Nutrition and Biomechanics, The Swedish School of Sport and Health Sciences, GIH, Stockholm, Sweden.

Cell Metabolism
|February 4, 2026
PubMed
Summary

Vigorous exercise shows a J-shaped effect on cognitive decline, with optimal benefits around 1,000-1,300 MET-minutes/week. Excessive physical activity can harm cognitive function by disrupting brain synapses.

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