Racial and ethnic disparities in postnatal growth of infants born before 30 weeks of gestation

Fu-Sheng Chou1,2,3,4, Hung-Wen Yeh5,6, Crystal Hsueh7

  • 1Southern California Permanente Medical Group, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org.

Insights

Racial and ethnic disparities affect premature infant growth. Black infants had lower birth weight z-scores but regained weight fastest, while Hispanic infants showed the slowest growth velocity.

Area of Science:

  • Neonatology
  • Pediatric Growth Studies
  • Perinatal Health Disparities

Background:

  • Premature infants (<30 weeks gestation) experience unique growth trajectories.
  • Understanding racial and ethnic variations in growth is crucial for optimizing care.
  • Existing data on disparities in early growth phases for extremely preterm infants is limited.

Purpose of the Study:

  • To investigate racial and ethnic disparities in birth weight (BW), time to BW regain, and mean growth velocity.
  • To analyze growth patterns in infants born between 23 and 29 weeks' gestation across different racial/ethnic groups.

Main Methods:

  • Retrospective analysis of a de-identified dataset (2010-2020) from Pediatrix Medical Group.
  • Inclusion of 76,145 infants born between 23-29 weeks gestation.
  • Utilized inverse propensity weighting to balance antenatal confounders across racial and ethnic groups (Asian, Hispanic, Black, White, Other).

Main Results:

  • Black infants exhibited the lowest BW z-scores compared to White infants, but achieved BW regain fastest.
  • Hispanic infants demonstrated the lowest mean growth velocity during the accelerated growth phase.
  • Significant racial and ethnic variations were observed in multiple postnatal growth parameters.

Conclusions:

  • Postnatal growth disparities in extremely preterm infants are complex and vary by growth phase.
  • Racial and ethnic background influences birth weight, weight regain, and growth velocity in preterm neonates.
  • Tailored interventions may be necessary to address specific growth challenges faced by different racial and ethnic groups.
Abstract

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