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Updated: Feb 6, 2026

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
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Versatile Chitosan-Based Hydrogel Dressings for Multi-Scenario Wound Management.

Ling Jiang1, Xuemei Wang1, Hui Jiang1

  • 1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)
|February 5, 2026
PubMed
Summary
This summary is machine-generated.

Chitosan (CS) hydrogels offer advanced wound healing by mimicking the extracellular matrix. These smart dressings provide biocompatibility, antimicrobial properties, and self-healing capabilities for both acute and chronic wounds.

Keywords:
chitosandressingshydrogelswound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Severe skin defects necessitate functional dressings for effective healing.
  • Hydrogels, particularly chitosan (CS)-based ones, are ideal for wound management due to their hydration, porosity, and biocompatibility.
  • CS hydrogels can be engineered with dynamic cross-linking for adaptable wound microenvironment integration.

Purpose of the Study:

  • To review the design principles and functional optimization of chitosan-based hydrogels for wound healing.
  • To highlight recent advancements in smart CS hydrogel dressings.
  • To discuss the potential of CS hydrogels in addressing challenges in both acute and chronic wound treatment.

Main Methods:

  • Review of literature on chitosan hydrogel development for wound healing.
  • Analysis of various cross-linking strategies (dynamic covalent and physical interactions).
  • Examination of functional properties including biocompatibility, hemostasis, antimicrobial activity, and stimulus-responsiveness.

Main Results:

  • Smart CS hydrogels exhibit enhanced functionalities: biocompatible, biodegradable, hemostatic, adhesive, antimicrobial, antioxidant, anti-inflammatory, stimulus-responsive, controlled-release, and self-healing.
  • These hydrogels accelerate healing in acute wounds via hemostasis and infection control.
  • For chronic wounds, CS hydrogels overcome barriers through synergistic effects like photothermal therapy, antimicrobial action, and promotion of vascular regeneration.

Conclusions:

  • Chitosan-based hydrogels represent a promising platform for advanced wound healing dressings.
  • Their tunable properties and diverse functionalities address complex wound healing challenges.
  • Future research should focus on further optimizing these hydrogels for clinical translation and broader applications in regenerative medicine.