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Baricitinib triggering a central nervous system inflammatory-demyelinating disease: A case report

Rozita Khalili1,2, Ahmad A Toubasi2, Meryim Poursheykhi3

  • 1Neuroimmunology Division, Department of Neurology, University of Tennessee Health Science Center (UTHSC), Memphis, TN, USA.

Multiple Sclerosis Journal - Experimental, Translational and Clinical
|February 5, 2026
PubMed
Summary

Janus kinase inhibitors (JAKis) like baricitinib can reduce inflammation but may trigger central nervous system (CNS) demyelinating diseases. This case highlights the potential risk of baricitinib exacerbating CNS inflammation, necessitating careful patient monitoring.

Keywords:
Janus kinase inhibitorbaricitinibcentral nervous systeminflammatory-demyelinating diseases

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