Clinical Age-reversal Quantification of a Facial Skincare Regimen with Sirtuin-targeting Ingredients in a Multiethnic...

Efficacy evaluations of topical cosmetic products purported to produce younger-appearing skin require an objective assessment of perceived age. The aim of this study is to quantify the age-reversal efficacy of a facial skincare regimen containing sirtuin-targeting and other anti-aging ingredients in a multiethnic population in terms of change in perceived age, using a validated age prediction model.

In this single-center, monadic study, eligible participants (n=72) applied a 3-product regimen (serum, soft crème, and eye crème) twice daily for 12 weeks. High-resolution digital photographs of subjects were graded for 7 facial parameters using an 11-point photonumeric scale (0=no signs of aging; 10=severe signs of aging) at baseline and 2, 4, 6, 8, and 12 weeks. Predicted Age scores derived from the model algorithm at each assessment point were compared with baseline scores to calculate change in Predicted Age in years.

Statistically significant decreases vs. baseline in calculated Predicted Age were observed as early as Week 2, with the difference increasing with continued product application (difference at Week 12 was -4.0 years). Each facial aging parameter improved at a different rate, with forehead lines and elongated cheek pores significantly improving as early as Week 2. Under eye lines and forehead lines showed the greatest calculated improvement over time.

Based on the Predicted Age model, the 3-product face/eye skincare regimen applied twice daily resulted in a significant decrease in calculated Predicted Age starting as early as 2 weeks, with continued improvement over time, and a decrease of 4.0 years by Week 12.