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A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and
Hamza Elhrech1, Oumayma Aguerd1, Meriem El Fessikh1
1Laboratory of Human Pathologies Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco.
Food Science & Nutrition
|February 5, 2026
Summary
This review summarizes Atractylone, a compound from Traditional Chinese Medicine (TCM), highlighting its diverse pharmacological effects and therapeutic potential. It provides a foundation for future research into this bioactive sesquiterpenoid.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Traditional Chinese Medicine (TCM)
Background:
- Atractylone, a bioactive sesquiterpenoid, exhibits a wide range of pharmacological activities, including cytotoxic, antimicrobial, anti-inflammatory, antiviral, anticancer, antioxidant, neuroprotective, and gastroprotective effects.
- Traditional Chinese Medicine (TCM) utilizes compounds with multifaceted therapeutic potential, broad biological targets, and favorable safety profiles.
- Despite its bioactivity, a comprehensive review summarizing current research on Atractylone is lacking.
Purpose of the Study:
- To systematically review and summarize the current state of research on Atractylone.
- To provide a detailed analysis of Atractylone's natural sources, biosynthetic pathways, and biological activities.
- To establish a foundation for future research and encourage exploration of Atractylone's therapeutic applications.
Main Methods:
- Systematic literature review conducted following the PRISMA guidelines.
- Comprehensive literature search performed across databases: PubMed, Scopus, Web of Science, and Google Scholar.
- Inclusion of all available information pertaining to Atractylone.
Main Results:
- Identification of Atractylone's natural sources and elucidation of its biosynthetic pathways.
- Detailed summary of Atractylone's diverse pharmacological activities, including cytotoxic, antimicrobial, anti-inflammatory, antiviral, anticancer, antioxidant, neuroprotective, and gastroprotective effects.
- Compilation of existing structural characterization data essential for optimizing pharmacological applications.
Conclusions:
- This review consolidates current knowledge on Atractylone, a promising bioactive sesquiterpenoid.
- The findings highlight the need for further research to fully understand and utilize Atractylone's therapeutic potential.
- This work serves as a crucial resource for researchers investigating Atractylone in medicinal chemistry and pharmacology.
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