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Related Concept Videos

Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

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In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
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Voltammetric Techniques: Cyclic Voltammetry01:10

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Cyclic voltammetry (CV) is an electrochemical technique used to investigate the redox properties of a chemical species. It involves measuring the current response of an electrochemical cell as a function of the applied potential. The setup for cyclic voltammetry typically consists of a working electrode, a reference electrode, and a counter electrode—all immersed in an electrolyte solution. The working electrode is where the redox reaction of interest occurs, while the reference electrode...
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Cyclic Processes And Isolated Systems01:19

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A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state. 
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Diels–Alder Reaction Forming Cyclic Products: Stereochemistry01:28

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The Diels–Alder reaction is one of the robust methods for synthesizing unsaturated six-membered rings. The reaction involves a concerted cyclic movement of six π electrons: four π electrons from the diene and two π electrons from the dienophile.
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Crohn's disease
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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Related Experiment Video

Updated: Feb 6, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Osilodrostat for Cyclic Cushing Disease.

Jane Rhyu1, Run Yu1

  • 1Division of Endocrinology, Diabetes, and Metabolism, University of California, Los Angeles (UCLA) David Geffen School of Medicine, Los Angeles, California.

AACE Endocrinology and Diabetes
|February 5, 2026
PubMed
Summary
This summary is machine-generated.

Cyclic Cushing syndrome, a rare condition, was effectively managed with osilodrostat. This medication demonstrated rapid, reversible inhibition of hypercortisolism, highlighting its potential for treating this challenging endocrine disorder.

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Pharmacology

Background:

  • Cyclic Cushing syndrome is a rare endocrine disorder characterized by intermittent episodes of hypercortisolism and spontaneous remission.
Keywords:
cyclic Cushing diseasecyclic Cushing syndromeosilodrostat

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  • Hypercortisolism poses significant mortality risks and is associated with numerous comorbidities, necessitating timely and effective management.