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Published on: August 21, 2021
A self-regulating wearable OLED patch for accelerated wound healing via photobiomodulation-triggered drug delivery
Hyejeong Yeon1, Sohyeon Yu2,3, Minhyeok Lee4
1School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. kyungcc@kaist.ac.kr.
Abstract:
The development of therapies that dynamically respond to the wound microenvironment is essential to overcome the limitations of conventional monotherapies. We present a wearable patch that self-regulates reactive oxygen species (ROS) to accelerate wound healing. This flexible organic light-emitting diode (OLED) patch conforms to the wound, delivering narrow 630 nm peak light at an irradiance of 5 mW cm-2 for photobiomodulation (PBM). The patch activates healing directly via PBM, and the consequently induced ROS serve as a therapeutic trigger. This ROS trigger stimulates ROS-responsive nanoparticles to release antioxidant drugs, which neutralize excess ROS. We confirmed a dose-dependent additive effect across 2-8 J cm-2, with 6 J cm-2 being the most effective. This combination therapy significantly accelerated wound closure and promoted superior tissue regeneration, including robust skin barrier reconstruction and mature vessel stabilization. This OLED patch introduces a next-generation phototherapy, transforming signals into therapeutic triggers for advanced combination treatments.
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