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Epstein-Barr Virus Infection at Single-Cell Resolution.

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This summary is machine-generated.

Single-cell and spatial-omics reveal Epstein-Barr virus (EBV) host interactions. This review highlights advances in understanding EBV pathogenesis for treating associated cancers and autoimmune diseases.

Keywords:
B cell lymphomaEBVNK/T cell lymphomaautoimmunityinfectious mononucleosismultiple sclerosisnasopharyngeal carcinomascATAC‐seqscRNA‐seqspatial‐omics

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Area of Science:

  • Virology
  • Immunology
  • Genomics

Background:

  • Epstein-Barr virus (EBV) infection research spans six decades.
  • Understanding virus-host interactions is crucial for treating EBV-associated diseases.
  • Single-cell resolution offers deep insights into EBV infection dynamics.

Purpose of the Study:

  • To review the current state of single-cell and spatial-omics in EBV research.
  • To discuss the evolution from characterization to functional single-cell studies.
  • To identify strategies for maximizing clinical insights from complex EBV datasets.

Main Methods:

  • Review of experimental models and clinical samples using single-cell and spatial-omics.
  • Analysis of historical trends and current adoption of single-cell assays.
  • Examination of end-to-end single-cell sequencing workflows.

Main Results:

  • Growing adoption of single-cell assays reveals emerging biological themes in EBV infection.
  • A shift towards functional single-cell studies is enhancing mechanistic understanding.
  • Spatial-omics provides context for cellular interactions in EBV pathogenesis.

Conclusions:

  • Single-cell and spatial-omics are transforming EBV research.
  • Future studies utilizing these techniques will address key questions in EBV pathogenesis.
  • Advances are critical for developing effective treatments for EBV-associated cancers and autoimmune diseases.