Related Experiment Video
Updated: Feb 7, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
Epstein-Barr Virus Infection at Single-Cell Resolution
1Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan, USA.
None:
Epstein-Barr virus (EBV) infection has been studied at single-cell resolution for six decades and counting. Such investigations can reveal virus-host interactions and their dependence on viral strain, cellular niche, infection program, immune response regulation, and time. Understanding these factors is paramount to treating EBV-associated cancers and autoimmune diseases. This review examines the state of the field in EBV single-cell and spatial-omics spanning experimental models and clinical samples. Topics of primary interest include the growing adoption and emerging biological themes from single-cell assays and analyses, the shift from characterization toward functional single-cell studies, and strategies to maximize clinically relevant insights from dense single-cell and spatial datasets. Ancillary topics include the historical evolution of the single-cell EBV field and end-to-end single-cell sequencing workflows. Special attention is given to open questions in molecular mechanisms of EBV pathogenesis and how they might be resolved by future studies utilizing single-cell techniques.
Related Concept Videos
What are Viruses?
Chromatographic Resolution
The effectiveness of separation can be evaluated by determining the level of separation between two neighboring peaks in a chromatogram, which represents the individual components of a sample.
In chromatography,...
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Introduction to Virus
Viruses of Archaea
Cancers Originate from Somatic Mutations in a Single Cell

