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Updated: Feb 7, 2026

Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
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Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor

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Conformational restriction of hinge carboxamide leading to potent lactam-based PKMYT1 inhibitors

Yazhou Wang1, Xiaomin Wang1, Chao Wang1

  • 1Insilico Medicine Shanghai Ltd, 9F, Chamtime Plaza Block C, Lane 2889, Jinke Road, Pudong New Area, China.

Bioorganic & Medicinal Chemistry
|February 5, 2026
PubMed

Keywords:
CADDConformation restrictionCyclization strategyPKMYT1 inhibitor

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