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Updated: Feb 7, 2026

Assaying Proteasomal Degradation in a Cell-free System in Plants
Published on: March 26, 2014
mRNA Translation and Proteasomal Degradation in Health and Neurological Disease
Alinny R Isaac1,2, Danielle Cozachenco2, Beatriz de A Wagner2
1Multidisciplinary Research Core in Biology (Numpex-Bio), Federal University of Rio de Janeiro, Duque de Caxias, RJ, Brazil.
Abstract:
The homeostasis of cellular proteins, i.e., proteostasis, is critical for neuronal function and brain processes. Proteostasis comprises a set of cellular mechanisms that control protein synthesis, folding, posttranslational modification, and degradation. Mounting evidence indicates that disruptions in such mechanisms may underlie several neurological diseases, including neurodevelopmental, neurodegenerative, and psychiatric diseases. In this review, we discuss molecular pathways involved in protein synthesis and degradation that are altered in several brain diseases, possible pharmacological approaches to correct these defects, and future perspectives for the field.
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