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Application progress of tRNA modification in gynecological tumors: A review

Pengfei Wang1, Xiaofei Chen2, Lujiadai Xue1

  • 1Department of Gynecology, The First Affiliated Hospital of Jinan University, Tianhe District, No. 613 West Huangpu Avenue, Guangzhou City, 510000, PR China.

International Journal of Biological Macromolecules
|February 5, 2026
PubMed

Insights

Transfer RNA (tRNA) modifications are crucial in gynecological cancers, influencing tumor growth and spread. Understanding these changes offers new avenues for precise diagnosis and treatment strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Transfer RNA (tRNA) is traditionally known for its role in protein synthesis.
  • Emerging research highlights tRNA chemical modifications as key players in tumor initiation, progression, and metastasis.
  • Gynecological malignancies pose a significant health challenge due to diagnostic delays and limited therapeutic options.

Purpose of the Study:

  • To review the role of tRNA modifications in gynecological cancers (ovarian, cervical, endometrial).
  • To elucidate the expression profiles and regulatory mechanisms of tRNA modifications in these cancers.
  • To explore the translational potential of tRNA modifications as biomarkers and therapeutic targets.

Main Methods:

  • Systematic review of current literature on tRNA modifications in gynecological cancers.
  • Analysis of expression profiles and regulatory mechanisms.
  • Exploration of correlations with malignant characteristics and translational potential.

Main Results:

  • tRNA modifications are linked to enhanced tumor cell proliferation, drug resistance, invasion, and metastasis in gynecological cancers.
  • Specific tRNA modifications show altered expression profiles and regulatory mechanisms in these malignancies.
  • These modifications demonstrate potential as biomarkers, therapeutic targets, and prognostic indicators.

Conclusions:

  • tRNA modifications represent a novel perspective for the precise diagnosis and management of gynecological tumors.
  • Further research into tRNA modifications could improve treatment strategies and patient outcomes.
  • Links between tRNA modifications, the tumor microenvironment, metabolic reprogramming, and immunotherapeutic response warrant further investigation.
Keywords:
Gynecological tumorMethylationPseudouridylationQueuosinetRNA modification

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