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The Convergence of Nanoscience and Stem Cells: A New Era in Cancer Therapeutics

Akshaya Priya Raveendran1, Ragavendran G1, Reya Rene Philip1

  • 1Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Chengalpattu, India.

Biotechnology Journal
|February 6, 2026
PubMed

Insights

Combining stem cell therapy and nanotechnology offers a promising approach to overcome challenges in cancer treatment, improving drug delivery and reducing toxicity. This interdisciplinary field holds potential for advanced targeted cancer therapies.

Area of Science:

  • Biomedical Engineering
  • Oncology
  • Regenerative Medicine

Background:

  • Cancer treatment faces limitations including poor drug distribution, systemic toxicity, and therapeutic resistance.
  • Stem cells possess tumor-homing abilities, self-renewal, and differentiation capacities, making them attractive for targeted cancer therapy.
  • Nanotechnology provides advanced platforms for drug delivery, imaging, and diagnostics with tunable properties.

Purpose of the Study:

  • To review the challenges in cancer drug delivery.
  • To elucidate the rationale for stem cell-mediated therapies in oncology.
  • To explore the role of nanotechnology in enhancing stem cell-based cancer treatments.

Main Methods:

  • Review of current literature on stem cell biology and nanotechnology in cancer therapy.
  • Analysis of the tumor-homing capacity of stem cells for targeted delivery.
  • Discussion of preclinical and clinical development status.

Main Results:

  • The convergence of nanotechnology and stem cell biology enables multifunctional strategies for targeted drug delivery, imaging, and diagnostics.
  • Stem cell tumor-homing can overcome major barriers in conventional cancer therapies.
  • Integration of nanotechnology enhances the potential of stem cell-mediated treatments.

Conclusions:

  • Stem cell-nanotechnology integration presents a promising avenue for advanced, targeted cancer therapies.
  • Addressing limitations and safety concerns is crucial for clinical translation.
  • Further research is needed to advance this interdisciplinary field and optimize therapeutic outcomes.
Keywords:
cancer therapeuticsdrug deliverynanocarrierprecision medicinestem cell nanotechnology

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