Gut Microbiota-Non-Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Area of Science:

• Immunology
• Microbiology
• Genetics

Background:

• Immune homeostasis is vital for organismal integrity, involving complex interactions.
• The gut microbiota-non-coding RNA (ncRNA) axis is a key regulator of host immunity.
• Microbial metabolites influence ncRNA expression, affecting immune responses.

Purpose of the Study:

• To review the molecular mechanisms of the gut microbiota-ncRNA-immune axis.
• To explore the role of this axis in immune-related pathologies.
• To highlight therapeutic strategies targeting this axis for precision immunology.

Main Methods:

• Literature review of existing research on the gut microbiota-ncRNA-immune axis.
• Analysis of molecular frameworks and pathogenic contributions.
• Identification of emerging therapeutic targets and biomarkers.

Main Results:

• Microbial metabolites can reprogram ncRNA expression, modulating immune cell functions.
• Dysregulation of the microbiota-ncRNA axis is linked to diseases like colorectal cancer, sepsis, atherosclerosis, and neuroimmune conditions.
• Microbial and ncRNA signatures show potential as diagnostic biomarkers and therapeutic targets.

Conclusions:

• The gut microbiota-ncRNA axis is a critical player in immune homeostasis and disease pathogenesis.
• Targeting this axis holds promise for novel therapeutic strategies in precision immunology.
• Understanding host-microbiota co-regulation is key for advancing immune health.