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Keratins' Advantages and Applications in Tissue Engineering: A Review
Yi-Ning Liu1, Xiao-Yan Wang1, Peng Yu1
1Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Abstract:
The main objective of this research is to systematically summarize the characteristics of keratin-based materials and their current applications in the tissue engineering field, with a particular emphasis on highlighting their unique advantages over other traditional protein-based materials (such as collagen and silk fibroin). An electronic literature search of PubMed, Web of Science, and Scopus was conducted, identifying publications related to keratin-based materials and their application in tissue engineering. The majority of literature was published between 2015 and 2025. The structure of keratins, which is rich in disulfide bonds, gives it unique advantages in the field of tissue engineering, such as sustainability, versatility, and controllable degradability. Future research in this area could focus on improving the brittleness of keratin, developing more stable extracting sources, such as marine-derived sources, and conducting long-term clinical trials.
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