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Updated: Feb 7, 2026

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A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
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Necrotizing enterocolitis in a patient with Microvillous Inclusion Disease: A case report
Inna Spector Cohen1,2, H Golden3, O Kobi1,4
1Pediatric Gastroenterology & Nutrition Institute, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Intestinal Failure (New York, N.Y.)
|February 6, 2026
Summary
Microvillous Inclusion Disease (MVID), a rare genetic disorder, can present with necrotizing enterocolitis (NEC). This case highlights the importance of careful enteral feeding management in MVID patients to prevent NEC complications.
Area of Science:
- Gastroenterology
- Pediatric Medicine
- Genetics
Background:
- Microvillous Inclusion Disease (MVID) is a rare congenital disorder characterized by severe infantile diarrhea, often necessitating long-term parenteral nutrition.
- MVID arises from MYO5B gene mutations, which impair brush border protein trafficking essential for intestinal function.
- Necrotizing enterocolitis (NEC) is infrequently associated with MVID, with limited prior case reports.
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