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Related Experiment Video

Updated: Feb 7, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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Neurobehavioral Changes in Fear Generalization in Clinical High Risk for Psychosis.

Jacqueline A Clauss, Baktash Babadi, Lauri Tuominen

    Medrxiv : the Preprint Server for Health Sciences
    |February 6, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Individuals at clinical high-risk for psychosis (CHR+) show wider fear generalization, suggesting altered associative learning may be a transdiagnostic risk factor for psychiatric illness, including anxiety symptoms.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Cognitive Psychology

    Background:

    • Altered associative learning is observed in psychiatric conditions, but its role as a transdiagnostic risk factor is unclear.
    • Understanding basic learning processes may reveal underlying vulnerabilities across different clinical states.

    Purpose of the Study:

    • To investigate fear conditioning and generalization in individuals with subclinical psychopathology, including those clinically high-risk for psychosis (CHR+).
    • To determine if altered fear generalization represents a transdiagnostic risk factor for psychiatric illness.

    Main Methods:

    • Functional magnetic resonance imaging (fMRI) was used to collect brain data during a fear conditioning and generalization paradigm.
    • Participants (N=72) included controls and individuals with subclinical psychopathology, 23 of whom were CHR+.
    • Psychometric modeling analyzed neural responses and memory ratings related to fear generalization.

    Main Results:

    • Individuals in the CHR+ group exhibited a significantly wider fear generalization curve, indicated by a greater threshold in left anterior insula responses.
    • Across all participants, anxiety symptoms correlated with a wider fear generalization threshold.
    • Expected fear generalization patterns were observed in the anterior insula, superior frontal gyrus, and memory ratings.

    Conclusions:

    • Specific alterations in fear generalization, a basic associative memory process, are linked to CHR+ status.
    • Wider fear generalization may serve as a transdiagnostic risk factor for psychiatric conditions, including psychosis and anxiety disorders.