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Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
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Accelerated multi-organ proteomic aging is detectable decades before dementia onset
Medrxiv : the Preprint Server for Health Sciences
|February 6, 2026
Summary
Midlife organ aging pace, not just current age, predicts future dementia risk and neurodegeneration. Advanced multi-organ aging, particularly brain and heart/muscle, synergistically increases dementia risk.
Area of Science:
- Gerontology
- Neuroscience
- Proteomics
Background:
- Proteomics research links organ aging to dementia risk.
- Longitudinal studies are needed to understand the temporal relationship between organ aging and neurodegeneration.
Purpose of the Study:
- To investigate the association between midlife organ age and the pace of organ aging with future dementia risk and neurodegeneration.
- To explore the synergistic effects of multi-organ aging on dementia risk.
- To identify proteins influencing the pace of multi-decade brain aging.
Main Methods:
- Longitudinal study design.
- Proteome-wide analysis in midlife.
- Mendelian randomization.
Main Results:
- Midlife organ age and its pace over decades predict dementia risk and neurodegeneration, independent of late-life organ age.
- Advanced multi-organ aging, especially combined brain and heart/muscle aging, synergistically increases dementia risk.
- Identified non-brain proteins, including TNFRSF1B, GM2A, and LSAMP, associated with the pace of brain aging, with TNFRSF1B causally linked to accelerated aging in multiple organs.
Conclusions:
- The pace of organ aging from midlife is a critical determinant of future dementia risk.
- Multi-organ aging, particularly brain and cardiovascular/muscle systems, poses a synergistic risk for dementia.
- Specific proteins may serve as therapeutic targets for mitigating age-related cognitive decline and neurodegeneration.
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