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Acute G6PD deficiency haemolytic crises with associated methaemoglobinaemia in a patient with typhoid

Jake P Jacob1,2, Midhun T John1,2, Gilad Mensky1,2

  • 1Department of Infectious Diseases, Faculty of Health Sciences, Helen Joseph Hospital, Johannesburg, South Africa.

Southern African Journal of Infectious Diseases
|February 6, 2026
PubMed

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder that increases red blood cell susceptibility to oxidative damage. While haemolysis is common, methaemoglobinaemia is a rare complication. A 39-year-old man developed both conditions, triggered by Salmonella typhi infection. Diagnosis was supported by Heinz bodies and blister cells on blood smear. Methylene blue and high-dose ascorbic acid were relatively contraindicated because of ongoing haemolysis and renal dysfunction.

Keywords:
G6PD deficiencyhaemolytic crisesmethaemoglobinaemiatyphoid

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